Harbaugh said Osemele will be placed on season-ending injured reserve and will soon undergo back surgery.
"He's headed to IR. He's working right now with the doctors and with his representative to find what type of surgery he wants to do and then find the best person to do it," Harbaugh said. "So we're going to go ahead and get that fixed."
It's expected to be a three-to-four month recovery for Osemele, so he'll be back in time to get ready for 2014.
"He'll be back early in the offseason program," Harbaugh said.
"Jimmy came in feeling better today," Harbaugh said. "He had a little groin strain in there and we thought it was better for Chykie (Brown) to play during the game, the trainers did. We'll keep working on that throughout the course of the week and we'll see how that develops in some of our practices Wednesday, Thursday, Friday."
Jackson was suspended the first eight games of the season for violating the NFL's policy on performance-enhancing substances. The second-year defensive back is eligible to return Sunday against Cincinnati, but Harbaugh isn't yet sure whether Jackson will.
"We're going to take a good look at it this week, see where he's at," Harbaugh said. "Asa says he's been working hard, that he's in great shape. He's working with trainers in Arizona and Los Angeles, and some football trainers working on some football-related stuff. Hopefully he's in that kind of shape where he can slide right in there and help us. We'll see if he can help us this week. If he can, with our situation at corner, that could be a plus for us. So I'm not ruling that out. It's a possibility."
The Ravens currently have just four cornerbacks on the roster, so adding Jackson would provide the defense with some much-needed depth. Jackson, if in game shape, would provide the Ravens with a speedy option in the secondary and on special teams.