Paul Konerko doubled with two outs in the first inning, but he was stranded.
Then the floodgates opened.
A.J. Pierzynski led off the second with a 394-foot home run. Alex Rios, batting .215 before tonight, doubled to left field and scored on a single by Adam Dunn, who was batting .163.
Guthrie got ahead of Gordon Beckham, 0-2, and served up another home run. This ball traveled an estimated 382 feet.
Juan Pierre doubled down the right field line with two outs, but he was thrown out trying to stretch it into a triple. Score it 9-4-5.
White Sox 4, Orioles 0.
Guthrie has thrown 40 pitches, 28 for strikes.
Update: The Oriole scored twice in the bottom of the third after Chicago left-hander John Danks retired the first six batters he faced. Matt Wieters led off with a double and scored on Josh Bell's one-out single. Bell took third on J.J. Hardy's double, and he scored on Nick Markakis' sacrifice fly.