SARASOTA, Fla. - Robert Andino's two-out double in the bottom of the fourth inning scored Mark Reynolds, who also doubled, and increased the Orioles' lead to 5-2.
The Red Sox loaded the bases with one out in the fifth against Brad Bergesen, but a double play ended the rally.
Bergesen tossed three scoreless innings, allowing three hits and walking two. Kevin Gregg has replaced him in the sixth.
Jason Hammel left today's game after two innings because his pitch count rose to 59.
"A lot of foul balls today," he said. "One of those days where I was making pretty good pitches and they just weren't putting them in play. I had my share of bad pitches in there, too, but I was just getting my work in and making sure I get to a certain point with the amount of pitches and just getting ready for the season. No reason to get hurt."
Hammel threw 39 pitches in the second while giving up two runs and three hits, and walking two batters.
"It's frustrating," he said. "I was making pretty good pitches. A lot of foul balls, extended innings with the heat. You can make all the excuses in the world, but I'm pretty pleased with the work today, no matter what the line would be.
"The slider was real good. The changeup and curveball went missing today, for some reason. I think I was rushing a little bit, but other than that, I'm not disappointed with anything today. I made some good pitches and they fouled them off, and I did what I did when I needed to make a pitch. I feel good."
Update: Andino drove in another run in the sixth with a two-out single that scored pinch-runner Scott Beerer. Orioles 6, Red Sox 3.
Matt Wieters and Steve Tolleson also singled in the inning.
Kevin Gregg gave up a run in the top of the sixth.
Update II: The Orioles defeated the Red Sox 6-5.