Pearce, leading off and playing left field, went 2-for-4 with an RBI. He also committed a fielding error.
Pearce hasn't played since June 19 in Detroit. He was batting .235/.311/.383 with three doubles, three homers and nine RBIs in 28 games before going on the disabled list with left wrist tendinitis. He had seven walks and 20 strikeouts in 81 at-bats.
Pearce underwent an MRA on his left wrist while in Sarasota - which involves injecting dye - to determine whether he had sustained a broken bone.
The Orioles can keep Pearce on a rehab assignment for a maximum of 20 days. He's out of minor league options and would have to be activated from the disabled list or designated for assignment.
Pearce was replaced in left field today by Andres Aguilar, who's attempting to become the first Guatemalan player to make the majors.
Here's the Red Sox lineup for tonight's game at Camden Yards:
Jacoby Ellsbury CF
Shane Victorino RF
Dustin Pedroia 2B
Davis Ortiz DH
Mike Napoli 1B
Daniel Nava LF
Jarrod Saltalamacchia C
Stephen Drew SS
Jose Iglesias 3B
John Lackey RHP