Chris Davis led off the bottom of the fifth inning with his 46th home run, the ball disappearing over the flag court in right field to give the Orioles a 4-2 lead.
Davis tied Jim Gentile for third place on the Orioles' single-season home run list. Frank Robinson his 49 in 1966 and Brady Anderson hit 50 in 1996.
Davis has 25 homers at Camden Yards this season, tying Rafael Palmeiro's record set in 1998. Robinson has the most home runs in one season in Baltimore. He hit 27 at Memorial Stadium in 1966.
Davis has 21 homers against American League East opponents. According to STATS, that's the most by a player within his division, ahead of Edwin Encarnacion's 19, Evan Longoria's 17 and Miguel Cabrera's 16.
Davis' 41 homers against the AL East over the past two seasons is the most by any player against any division since the start of 2012.
Davis home run tonight was the 74th to land on Eutaw Street. in the history of Camden Yards, the fifth in Davis' career and his second this year. It also happened on Aug. 2 against the Mariners.
It's the 30th Eutaw. St. home run by an Oriole.
Davis has each of the Orioles' last four Eutaw Street home runs, and five of the last six.
Update: Opponents were hitting .306 against Wei-Yin Chen in the sixth inning this season, and .333 in the seventh. He blanked the Rays in both innings tonight and continues to hold a 4-2 lead.
Chen retired the side in order in the sixth and got Sam Fuld to ground into a double play to end the seventh and survive a leadoff walk.
Darren O'Day warmed in the bullpen as Chen threw his 98th pitch and returned to the dugout.
Chen has allowed two runs and six hits in seven innings, with three walks, three strikeouts and two home runs.
Update II: The Orioles avoided the sweep by defeating the Rays 4-2 before 28,323 at Camden Yards.
Darren O'Day retired the side in order in the eighth and came back out in the ninth in a save situation.
Tommy Hunter and Brian Matusz warmed in the eighth. Jim Johnson began to stretch, but he sat back down.
O'Day threw eight pitches in the eighth. Given the ball again in the ninth, he gave up a leadoff single to Wil Myers with the count full and was replaced by Matusz.
Pinch-hitter James Loney drew a walk to win an 11-pitch battle with Matusz, who was replaced by Hunter with runners on first and second and no outs.
Pinch-hitter Matt Joyce flied to center. Pinch-hitter Kelly Johnson, 6-for-18 with a double and three home runs lifetime against Hunter, grounded into a force at second. Jose Lobaton came to the plate, Johnson tried to steal and Matt Wieters cut him down.
Hunter picked up his fourth career save, all of them coming this season.
The Orioles are 14-5 in two-run games.