Adam Jones homered with two outs in the bottom of the first inning to give the Orioles a 1-0 lead.
Jones drove a Bronson Arroyo pitch an estimated 394 feet to center field for his 13th homer.
Jones has recorded at least one RBI in seven straight games, raising his team-leading total to 45. He's tied with Mark Reynolds for the club's home run lead.
Brian Matusz threw 15 pitches in a scoreless first inning, and the stadium radar gun clocked his fastball in the 88-90 mph range. Matusz struck out Cincinnati's leadoff hitter, Chris Heisey, on an 89 mph fastball.
Joey Votto singled with two outs before Scott Rolen grounded into a force. Jones didn't appear to get a good read on Votto's ball, and it fell in front of him.
Matusz hasn't completed the sixth inning in any of his four starts before tonight. He left last Saturday's game in Washington after 5 1/3 because of cramping in his left hamstring.
Instant update: Jonny Gomes just tied the game in the top of the second inning with his 10th home run. Gomes crushed an 86 mph fastball.