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The Orioles fell to 7-13 in series finales, including 4-7 at home.
Jeremy Guthrie failed to pitch into the sixth inning for the third time this season.
"Jeremy wasn't carrying normal stuff and it was kind of a struggle for him most every inning," manager Buck Showalter said. "He was kind of wild in the strike zone and paid the price, but there's still a game there to be won. We had some opportunities. We're ball four away from getting the tying run to the plate there. Obviously, it was ball four."
Showalter is referring to Robert Andino's strikeout to end the game. Plate umpire Kerwin Danley must have wanted to rush over to the Federal Hill Festival.
Buck Showalter talks to the media about the O's frustrating 7-4 loss to the Blue Jays
Here's more from Showalter on Guthrie:
"You guys have seen him good, which is most of the time. Today wasn't one of those days. It happens, unfortunately. The sixth run was a kicker for us. We're sitting there, 5-2, we have a good pop at it. We had some good swings, centered up some balls today."
Jo-Jo Reyes gave up two runs in the first inning, then nothing more until the fifth. He allowed three runs and five hits, with four walks, in 6 1/3 innings.
Did Showalter expect to have a lot of scoring chances against Reyes after that first inning?
"I think we did except for two or three innings. We were always just one pitch away," he said. "The whole series they were pitching us hard in a lot, using cutter, cutter, cutter in there, very little over the plate. We made a pretty good adjustment to them. I think we hit three line drives at them that we didn't get much to show for. That was frustrating."
Showalter said he'll wait until tomorrow to announce Tuesday's starter. We know it's not Alfredo Simon after the right-hander threw 50 pitches in three innings and allowed one run and two hits, with one walk and three strikeouts.
"Let the smoke settle a bit," Showalter said. "He probably wouldn't be an option with just one day off after that number of pitches, but it also presents an opportunity to potentially get him back Tuesday out of the bullpen. Probably won't be Alfredo."
Luke Scott didn't play today after having an injection in his ailing shoulder, and he'll be out of the lineup tomorrow night against Oakland left-hander Gio Gonzalez.
"I probably could have pushed the envelope on him a little with the left-hander today and a left-hander tomorrow," Showalter said. "Just trying to see if we can free that up a little bit. And didn't like the option there."
Asked if the Orioles are reaching a point where they might have to put Scott on the disabled list, Showalter replied, "It's something he's been playing with. Only Luke really knows because he's not giving it up very much, at least not to me, and I talk to him about every day in some form or fashion. He's a tough guy. He's going to try to play through it and we're hoping this injection kind of frees it up a little bit. If not, then what you're talking about is something that we might revisit.
"They did it (the injection) before the game and he told me that he thought he could probably pinch-hit, but for me that wasn't an option and I certainly wasn't going to broadcast it before the game."