Jeremy Guthrie continued to give up home runs tonight and the Orioles continued their season-long struggles vs. Boston.
The Red Sox hit three homers off Guthrie in a 6-5 win over the O's on Friday night in front of 44,091 at Camden Yards.
The O's fall to 2-9 on the season vs. Boston.
Aubrey Huff hit his 200th career homer, a two-run shot in the last of the 6th to give Baltimore a 5-4 lead. But in the 7th, a Kevin Youkilis two-on, two-out homer put Boston on top 6-5.
Earlier, David Ortiz hit a two-run homer and Jacoby Ellsbury, who had three hits, hit a solo shot.
Guthrie, now 7-10, 5.37, gave up nine hits and six runs in 6 2/3 innings. He has now given up 26 homers on the season.
Winning pitcher John Smoltz, 2-4, gave up five runs over six innings. Jonathon Papelbon got the last three outs for his 27th save.
Nolan Reimold and Huff hit two-run homers for the Orioles, who fall to 4-10 since the All-Star break.