The Orioles will lose another series, no matter what happens tomorrow afternoon - including a possible postponement because of rain. They're 0-12-1 in their last 13 series.
The Orioles have lost five one-run games on this homestand after being 10-1 in one-run games at Camden Yards.
Tonight's defeat lowers the Orioles' record to 45-72, putting them on pace for 100 losses.
Vladimir Guerrero is 4-for-8 with a home run and three RBIs in two games since moving down to fifth in the order.
Jeremy Guthrie lasted 5 2/3 innings tonight, breaking a streak of pitching seven innings in five consecutive starts.
Guthrie got two outs in the sixth before six consecutive Tigers reached base and a 5-1 lead turned into a 6-5 deficit.
"Just centered a lot of balls," manager Buck Showalter said. "He's got two outs and nobody on and pitching pretty well against a very good club, and that's hard to do at any time. You're a pitch away. And obviously we're a little challenged down at the bullpen that point in the game. Gave up a ground ball (to Ryan Raburn), that last one that just found a good hole, but they centered some balls up, obviously. The 3-0 pitch hurt him. They got into some counts there.
"At this level and especially a team up and down the order, you've got a guy like (Alex) Avila and (Wilson) Betemit hitting down there, it can happen anytime. You don't ever assume something like that can't happen. You don't look at it that way. I don't anyway."
The Orioles scored five runs off Max Scherzer in the second inning on home runs by Guerrero and Blake Davis. Then they shut down.
"That was the key to it," Showalter said. "We had that one inning. After that, there were pretty much not any opportunities. You have to give credit to Scherzer. That's why they're leading their division. So many little things there in a one-run ballgame. We like our chances, but we couldn't get that one hit."
Scherzer threw 43 pitches in the second inning, but he lasted seven innings and 120 pitches.
"He got better," Showalter said. "Usually against good starting pitching, you have a point in the game where you've a shot at them and you take advantage of it, which we did. It just wasn't enough. We didn't do a whole lot after that. That's the first big inning we've had in a while, where we put a lot of runs up there, but I really would have liked to see us tack on. He was there to get out of the game with a few more good at-bats."