This time Andy Marte hit his game-winning homer in the 6th inning, not in the 9th.
Not long after the game resumed after a rain delay of one hour and 37 minutes, Chris Ray took the mound in the 6th replacing starter Chris Tillman.
Marte came up with Cleveland trailing 2-1. With two men on, he hit a pitch from Ray over the left field wall for a 4-2 lead and Cleveland went on to a 5-3 win on Saturday night in front of 24,358 at Camden Yards.
Marte's two-run homer with two outs in the top of the 9th Thursday gave Cleveland a 5-4 win.
Tillman did not get a decision. He gave up one run and six hits over five innings.
For the Orioles, Nick Markakis had an RBI double, Cesar Izturis an RBI triple and Chad Moeller a solo homer.
Rafael Perez, who pitched 1 1/3 innings of shutout relief, got the win. Matt LaPorta went 4 for 4 for the Tribe.
Adam Jones had quite a night on defense. He made two leaping catches at the wall, robbing Asdrubal Cabrera and Shin-Soo Choo of at least extra-base hits if not homers, plus he threw a runner out at the plate in the 8th inning.