For the second day in a row, the Toronto Blue Jays used the home run ball to beat the Orioles.
Lyle Overbay led off the last of the 11th and hit an 0-1 pitch from Mark Hendrickson over the right field wall for a 5-4, walk-off win.
That was the Jays fourth homer of the game and seventh of this series. The Jays have hit a Major League-leading 241 on the season.
The Orioles have now lost three in a row and are 0-8 on the year at Rogers Centre. They have lost 13 straight and 22 of their last 24 games in Toronto.
Jim Hunter talks with Buck Showalter about the O's walk-off loss to the Blue Jays
The O's led twice in the game, but could not hold 3-0 and 4-3 leads.
The Birds fall to 13-4 in extra-innings and are now 3-14 on the season vs. Toronto.
The Orioles took a 3-0 lead in the top of the second on a Brandon Snyder RBI double and back-to-back bases-loaded walks off Ricky Romero to Julio Lugo and Nick Markakis.
Toronto got solo homers from Aaron Hill and Travis Snider to make it a 3-2 game and tied it on a Lyle Overbay sac fly in the 6th.
The teams exchanged solo homers in the 7th as Ty Wigginton hit his 22nd in the top half of the inning and then Edwin Encarnacion delivered in the bottom half for a 4-4 tie.
Jeremy Guthrie gave up four runs and seven hits over 6 1/3 in a no decision. O's starters now have just one quality start and an ERA of 6.32 over the last seven games.
Guthrie now has pitched 201 1/3 innings on the season and is the first O's pitcher with back-to-back, 200-inning seasons since Mike Mussina and Sidney Ponson did that in 1999 and 2000.