Guthrie on his game, pitches Orioles past Boston

Prior to tonight, the Boston Red Sox had hit .350 and scored 47 runs in their last five games against the Orioles.

But tonight, Jeremy Guthrie held that team to just two runs over seven innings as the Orioles beat Boston 6-2, to end a seven-game losing streak against the Red Sox.

Guthrie, who had given up 12 runs in his last two starts over 10 innings, allowed eight hits and two runs, throwing 110 pitches.

Jeremy Guthrie tells the media what he did to cool off the Red Sox hitters in the O's win

Guthrie improves to 4-13 with an ERA of 4.35. This was just his second career win over Boston. He entered with a record of 1-7 and 4.62 ERA in 15 starts. Guthrie had just one win since the end of May. Jarrod Saltalamachia hit a two-run homer in the fifth for the only Boston runs.

Jim Johnson retired the top of the Boston order in the eighth and before the Orioles turned a 3-2 lead into a 6-2 edge in the last of the inning. Derrek Lee's two-run homer made it 5-2 and Mark Reynolds followed with a solo shot, number 21 on the year, to put the O's up four runs.

Reynolds had ended an 11-game RBI drought with a run-scoring double in the second that gave the O's a 1-0 lead and a Nolan Reimold RBI grounder made it 2-0. Matt Wieters knocked in a run an inning later off losing pitcher Kyle Weiland.

Boston entered with the best record in the majors in July at 12-2 and best road record in MLB at 30-19.

In the series finale Wednesday afternoon at 12:35, Jake Arrieta (9-6, 5.10) pitches for the Orioles against Andrew Miller (3-1, 5.68).

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