Hanser Alberto went 3-for-5 with two runs scored in the Orioles' 7-2 win over the Red Sox on Saturday.
John Means was originally scheduled to make the Orioles' opening day start before being scratched due to arm fatigue.
Chris Davis will play first base and bat fifth on Friday against the Red Sox in the Orioles' season opener.
In Ryne Harper's Nationals debut, the right-hander tossed two scoreless innings and recorded four strikeouts.