The latest attempt to get Jackson Holliday through an injury rehab assignment without any issues already has failed.

Holliday returned to Triple-A Norfolk tonight after playing two games with High-A Frederick. He struck out on a foul tip in the first inning and was removed due to “right hand discomfort,” according to the Orioles.

The at-bat lasted four pitches. Willy Vasquez moved from left field to second base.

A video shows Holliday in obvious pain after the strikeout. He removed his hand from the bat, shook it and grimaced after spinning out of the box.

Holliday underwent surgery on Feb. 12 to remove a broken hamate bone. He reported to the Tides for their Opening Day on March 27 and played in 11 games, going 7-for-42 (.167) with two doubles, three walks and 12 strikeouts.

The Orioles brought him back to Baltimore, where he participated in fielding drills and took batting practice on April 13. They shut him down for a few days because of lingering soreness in the wrist, which they described as normal for many players following the procedure.

“Each player’s different, either how the surgery went, how they’re recovering, how they’re dealing with whatever it is. But to me, that’s common,” manager Craig Albernaz said last week.

“Last year, Chase DeLauter had a similar injury and he had some discomfort for an extended period of time, too. I’m not saying Jackson is in that same scope, but it is common to have some type of whatever feeling, soreness, whatever it is.”

A weekend appearance with the Keys provided eight at-bats for Holliday. He had two hits, including a double, and an RBI.

Minor league teams were off yesterday. Holliday batted second tonight against Memphis at Harbor Park and was pulled from the game.

Matt Holliday provided an update on his son on a recent appearance on Foul Territory.

“He had some soreness on the opposite side, which, sometimes you kind of compensate with some stuff, so his wrist on the opposite side got a little bit sore,” Matt said. “He went back to Baltimore and got some reassurance that everything was fine and he just had some inflammation on the other side of his wrist, and so, taking some anti-inflammatories.

“He’s working his way back. Obviously, don’t want to rush it, make sure he feels strong and ready. … I think it’s just being cautious with the wrist and making sure when he does get activated that he’s 100 percent confident where he’s at physically so he can get out there and compete at the highest level that he can.

“There’s just little hiccups here and there, but he’s close and feeling good.”

Holliday avoided the injured list last season, a rarity on this club, and batted .242/.314/.375 with 21 doubles, three triples, 17 home runs and 55 RBIs in 149 games. Jeremiah Jackson has become the regular second baseman and leads the Orioles with 17 RBIs while slashing .296/.311/.535 with five home runs.