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BOSTON – The Orioles will try for the series win this afternoon with the latest outfield alignment putting Terrin Vavra in left field.

Three games and three different left fielders, including Anthony Santander on Opening Day and Ryan McKenna last night.

Jorge Mateo is out of the lineup after sustaining two cuts on his right index finger last night. He stayed in the game and said he was fine, but Gunnar Henderson is playing shortstop and Ramón Urías is at third base after he struck out five times last night.

Urías drops from the leadoff spot to ninth.

Santander remains the designated hitter and Austin Hays is in right field. Kyle Stowers is on the bench again.

Adley Rutschman is catching Cole Irvin, who’s making his first appearance at Fenway Park.

Right-hander Tanner Houck has faced the Orioles five times and allowed three earned runs with 18 strikeouts in 14 2/3 innings. Today marks his second start against them.

For the Orioles
Cedric Mullins CF
Adley Rutschman C
Anthony Santander DH
Ryan Mountcastle 1B
Gunnar Henderson SS
Terrin Vavra LF
Austin Hays RF
Adam Frazier 2B
Ramón Urías 3B

Cole Irvin LHP

For the Red Sox
Rob Refsnyder LF
Rafael Devers 3B
Justin Turner 1B
Masataka Yoshida DH
Adam Duvall CF
Alex Verdugo RF
Christian Arroyo 2B
Kiké Hernández SS
Connor Wong C

Tanner Houck RHP