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BOSTON – Ramón Urías is batting leadoff today for the first time in 215 major league games. He’s starting at second base.

Manager Brandon Hyde adjusted his lineup with left-hander Chris Sale starting for the Red Sox. Cedric Mullins moves down to eighth.

Anthony Santander goes from left field on Opening Day to designated hitter. Ryan McKenna is batting ninth and playing left. Austin Hays stays in right.

Gunnar Henderson is at third base.

Dean Kremer is making his sixth career start against the Red Sox. He’s 0-4 with a 6.85 ERA and 1.690 WHIP in 23 2/3 innings.

Kremer has allowed 14 runs and 19 hits with eight walks in 13 1/3 innings at Fenway Park.

Alex Verdugo is 5-for-14 with two doubles and a home run against Kremer. Rafael Devers is 3-for-11 with a double and home run.

Sale is 10-3 with a 2.71 ERA and 1.035 in 23 career appearances (17 starts) against the Orioles. Austin Hays is 3-for-11 with two home runs.

For the Orioles
Ramón Urías 2B
Adley Rutschman C
Ryan Mountcastle 1B
Anthony Santander DH
Austin Hays RF
Gunnar Henderson 3B
Jorge Mateo SS
Cedric Mullins CF
Ryan McKenna LF

Dean Kremer RHP

Reliever Keegan Akin is celebrating his 28th birthday today.

For the Red Sox
Alex Verdugo RF
Rafael Devers 3B
Justin Turner DH
Masataka Yoshida LF
Adam Duvall CF
Triston Casas 1B
Christian Arroyo 2B
Reese McGuire C
Kiké Hernández SS

Chris Sale LHP

Here are the starters for the upcoming series in Texas:

Monday: Kyle Bradish vs. Jon Gray
Tuesday: Tyler Wells vs. Andrew Heaney
Wednesday: Kyle Gibson vs. Jacob deGrom